When do you say 'Enough!'

I'm sitting here in front of my computer, reviewing all the jobs I've applied for and for which I didn't get an interview, and looking over the list of people I've contacted who can't even muster the effort to make a one-minute return phone call or even send a one-sentence reply.

And I ask myself, "What is the point? Why am I putting myself through all this nonsense just to try to get a job here? Just write off the Pittsburgh area, pack a bag, and get the hell out of this town before your career goes into even more of a death spiral."